Table 3. Inhibition of HCV Replicons for Approach B Heteroaromatic Compounds 31–37^a.

^aSee the Supporting Information for assay details, number of replicates, 95% confidence intervals, and cellular toxicity data (CC₅₀). Confidence intervals were derived from a pooled SD calculated for each assay in log space (i.e., pEC₅₀), where replicates are normally distributed; pooled assay SDs are supplied parenthetically in the following notes.

^bGT 1b WT (SD = 0.21 log units) and 316N (SD = 0.24 log units) assays used a stable replicon system, whereas GT 1a WT (SD = 0.23 log units) and 316Y (SD = 0.20 log units) were transiently transfected.