Table 5. In Vivo Rat PK Profiles of Second-Generation NS5B Inhibitors.

		i.v.a			p.o.b
Cmpd	series	Cl (mL/min/kg)	Vdss (L/kg)	t1/2 (h)	AUC (ng h/mL)	F (%)
1c	N-benzyl	29	1.4	1.0	700	23
11	indane	69	3.5	1.1	40	4
25	oxazolidinone	22	1.3	1.2	280	8
31	heteroaryl	4.5	0.9	2.6	7600	40
33		5.4	1.3	3.4	10000	64
47	N-phenyl	5.1	1.1	3.7	4800	27
49		6.9	0.9	2.8	5400	43

^aDosed i.v. at 1 mg/kg in DMSO/20% HP-β-CD (10/90).

^bDosed p.o. at 5 mg/kg in DMSO/20% HP-β-CD (10/90).

^cDosed i.v. at 1 mg/kg and P.O. at 5 mg/kg in DMSO/Solutol/4%HP-β-CD with 0.05% acetic acid (5/10/85) to CD rats (n = 3). Further details are provided in the Supporting Information.