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. 2019 Feb 14;62(7):3254–3267. doi: 10.1021/acs.jmedchem.8b01719

Table 6. Cytochrome P450 (CYP) Inhibition Data for the Second-Generation NS5B Inhibitorsa.

    IC50 (μM) (substrate probe)
Cmpd series CYP2C9 (diclofenac) CYP2C19 (mephenytoin) CYP3A4 (atorvastatin) CYP3A4 (midazolam) CYP3A4 (nifedipine)
1 N-benzyl 4.9 18 7.1 >33 28
31 heteroaryl 2.7 1.2 8.9 >33 >33
33   1.5 23 2.0 >33 >33
47 N-phenyl 2.6 7.4 4.2 >33 8.1
49   22 >33 >33 >33 >33
a

Experimental details are provided in the Supporting Information.