. 2019 Feb 14;62(7):3254–3267. doi: 10.1021/acs.jmedchem.8b01719

Table 7. In Vivo PK Plasma or Blood Clearance (Cl) in Mouse, Rat, Dog, and Cynomolgus Monkey.

	in vivo clearance [mL/min/kg], (% liver blood flow of species)^a
Cmpd	mouse	rat^b	dog^b	Cyno
1^c	1.4 (1.1%)	29 (37%)	11 (19%)	48 (∼100%)
49^b,^d	0.7 (0.6%)	6.9 (8.9%)	1.2 (2.1%)	5.7 (13%)

Cl as a percentage of liver blood flow is calculated as compound Cl (blood or plasma)/species hepatic blood flow. Hepatic blood flow estimates of 126, 77.6, 56.1, and 44 mL/min/kg were used for mouse (0.02 kg), rat (0.25 kg), dog (10 kg), and cynomolgus monkey (5 kg), respectively.²⁶

Blood clearance was used.

Dosed i.v. at 1 mg/kg in 5–10% DMSO/85–95% HP-β-CD (20% in sterile water) with or without solutol or DMSO/30% sulfobutylether- β-cyclodextrin (5/95).

Dosed i.v. at 1 mg/kg in DMSO/20% hydroxypropyl-β-cyclodextrin (10/90, pH adjusted).