Skip to main content
. 2019 Jan 28;10(4):437–443. doi: 10.1021/acsmedchemlett.8b00484

Table 3. Ionization, Lipophilicity, and Solubility of Compounds 1, 2, and INDO.

        solubility (mg/L)
cmpd pKa ± SDa c log Pb log D7.4 ± SD pH 2 SGF pH 7 SIF
INDO 4.41 ± 0.04 4.18 1.01 ± 0.03 7.19 1819.52
1 4.09 ± 0.03 5.21 1.80 ± 0.03 0.48 276.33
2 6.10 ± 0.01 4.54 3.1 ± 0.2 0.12 2.40
a

Potentiometric titration.

b

c log P calculated using Bio-Loom for Windows, version 1.5.