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. 2019 Feb 20;10(4):475–480. doi: 10.1021/acsmedchemlett.8b00509

Figure 4.

Figure 4

Compound VS1 decreases STARD3 protein stability. (A) NIH3T3 fibroblasts were treated with 100 μM of compound VS1 for 24 h followed by 10 μg/mL of CHX for the indicated time (hours). (B) STARD3 mRNA levels: cells were treated for 48 h at two different concentrations of VS1. The inhibitor does not affect the mRNA levels of target. (C) MDA-MB-231 cell line was treated with 100 μM of compound VS1 for 24 and 48 h. Western blot analysis shows that the level of FAK and pTyr397-FAK increase in treated cells.