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| species | F (%) | Clp (mL/min/kg) | Vdss (L/kg) | t1/2 (h) | AUCpob (μM–h) |
|---|---|---|---|---|---|
| mouse | 62 | 13 | 3.2 | 3.3 | 9.3 |
| rat | 100 | 20 | 5.3 | 3.3 | 21.5 |
| minipig | 30 | 20 | 0.64 | 3.7 | 2.6 |
Compound 6 was dosed as a tartrate salt.
Plasma exposure after oral administration of 20, 10, and 5 mg/kg doses in mouse, rat, and minipig, respectively. Data are normalized linearly downward to 5 mg/kg.
