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Schematic representation of (A) STDO. The single strand circular genome of M13mp18 is folded to form a DNA origami tube of 30 nm in length, through the hybridization of 113 rationally designed staple strands. (B) LSTDO. Pegylated liposomes were extruded in the presence of STDO to create a hybrid drug delivery system. Following, the preassembled LSTDO was actively loaded with doxo taking advantage by the intrinsic property of DNA to interact with anthracyclines.
