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. 2019 Jan 31;10(4):517–521. doi: 10.1021/acsmedchemlett.8b00557

Figure 5.

Figure 5

LSTDO attenuates the inflammation induced by DNA origami. (A) ELISA test on FVB/N mice. Mice (two groups of four mice) were treated with STDO, LSTDO, and liposomes to detect acute inflammation. After 6 h, blood was collected and analyzed: IL-6 increased in mice treated with STDO (*p-value < 0.05). (B) Evaluation of interferon activation in THP1 monocytic cell line. THP1 cell line was modified in order to secrete a luciferase under the control of interferon pathway. Cells were treated with 10 and 100 μg/mL of STDO, LSTDO, and liposomes. Interferon production was enhanced by the treatment with STDO (**p-value < 0.01; * <0.05). (C) Schematic representation of the TLR9 stimulation by STDO and LSTDO.