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. 2019 Jan 10;10(4):504–510. doi: 10.1021/acsmedchemlett.8b00534

Figure 2.

Figure 2

(A) Effect of 3f and 13 at 500 and 1000 nM in antagonizing SRC-1 recruitment on FXR by CDCA at 500 nM. Each measurement has been repeated in triplicate and SD < 5%. (B, C) Off-target activity. (B) HepG2 cells were stimulated with GW3965 (GW, 10 μM) or Rosiglitazone (ROSI, 500 nM), or Rifaximin (RIF, 10 μM) as positive controls and compounds 3f and 13 (10 μM); (C) cells were stimulated with 5 μM of compounds 3f and 13 in combination with the relative positive control. Results are expressed as mean ± SEM. *p < 0.05 versus not treated cells (NT).