Skip to main content
. 2019 Jan 10;10(4):504–510. doi: 10.1021/acsmedchemlett.8b00534

Table 2. In Vitro Pharmacokinetics for Compounds 3f and 13.

compound solubilitya (μM) log D Clintb t1/2 (min) %c
3f 200 0.34 20.67 111.8 76.2
13 110.4 0.58 201 11.5 9.4
a

Aqueous solubility at pH 7.4.

b

Reported as μL/min/mg protein.

c

Percentage of compound remaining in solution after 40 min of incubation. Each measurement has been repeated in triplicate and SD < 5%.