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Nox isoforms and subunits. Diagram showing subunit requirements for the isoforms 1–4 of NADPH oxidase (Nox). In addition to the base Nox enzyme, p22phox is constitutively required across Nox1–4. While Nox4 does not require any further subunits before ROS generation can commence, Nox1–3 require additional organizational and activator subunits. NOXO1 = NADPH oxidase organizer 1; NOXA1 = NADPH oxidase activator 1.
