Table 3.

Summary of trials for the use of ceftaroline in adult patients with MRSA infection. (ABSSSI = Acute bacterial skin and skin structure infection; CABP = community-acquired bacterial pneumonia; SAB = Staphylococcus aureus bacteremia).

Criteria	Ho et al. [20]	Casapao et al. [21]	Vazquez et al. [22]	Lin et al. [23]	Polenakovitch et al. [24]	Sakoulas et al. [25]	Santos et al. [26]
Total number of patients who received ceftaroline, n	6	630	48 (27 with ABSSSI and 21 with CABP)	10	31	26	647
Patients with MRSA, n (%)	6 (100%)	241 (38%)	16 (59%) with ABSSSI and 16 (76%) with CABP	10 (100%)	31 (100%)	20 (76%)	191 (29%)
Patients who received antibiotics prior to ceftaroline	6	422	14 with ABSSSI and 13 with SAB	10	31	26	515
Duration of treatment with ceftaroline, median (range)	Varies per case	6 days	5.8 days for ABSSSI and 7 days for CABP	Varies per case	5 days	16 days	6 days
Number of patients that were treated with ceftaroline as monotherapy	6	447	22 in ABSSSI and 10 in CABP	-	-	none	114
Clinical success of MRSA patients, n (%)	5 (83%)	426/484 (88%)	8/16 (50%) with ABSSSI And 10/16 (63%) with CABP	6 (60%)	23 (74%)	23 (88%)	144/178 (81%)
Safety outcome	GI bleeding and death reported in one patient	8% hospital mortality 0.9% diarrhea 0.6% vomiting 1.1% renal failure	-	Rash, eosinophilia, pruritis and clostridium difficile infection	Eosinophilic pneumonia, rash and diarrhea	-	-