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. 2019 Apr 15;11:63. doi: 10.1186/s13148-019-0660-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Decreased 5mC and increased 5hmC in T2DM patients. a 5mC and b 5hmC contents in T2DM patients and controls. Linear regression analysis between glucose and c 5mC and d 5hmC in all subjects after controlling age and gender. e 5mC and (f) 5hmC contents in T2DM patients with (MD+) or without (MD−) macrovascular diseases and controls. 5mC and 5hmC contents were detected by HPLC-MS/MS, and data are expressed as the means ± SD