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. 2019 Apr 15;11:63. doi: 10.1186/s13148-019-0660-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Dynamic 5mC and 5hmC mediated by glucose stimulation. The levels of a glucose, b 5mC, and c 5hmC at five different time points (0, 30, 60, 120, and 180 min) of OGTT from diabetes patients. The levels of d 5mC and e 5hmC at five different time points (0, 30, 60, 120, and 180 min) of OGTT from controls. f 5mC and g 5hmC contents in diabetic rats and controls. The contents of 5mC and 5hmC were detected by HPLC-MS/MS, and data are expressed as the means ± SD