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. 2019 Apr 15;19:99. doi: 10.1186/s12935-019-0816-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Promoter methylation is responsible for the loss of OTUD4 expression in NSCLC cells. a Schematic illustration of the arrangement of the promoter region and the region for BSP analysis. b Expression of OTUD4 mRNA in indicated cells treated with or without 5-Aza-dc. c Methylation specific PCR analysis of genomic DNA of tumor tissues from 10 patients. d Methylation status of promoter CpG islands from 3 individual clones analyzed by BSP. Error bars represent SD from 3 independent experiments. *p < 0.05. BSP, bisulfite genomic sequencing