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. 2019 Apr 15;19:99. doi: 10.1186/s12935-019-0816-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — OTUD4 enhances cell cycle arrest and promotes cell apoptosis induced by IR. a Representative pictures of cell cycle distribution of indicated cells 12 h after irradiation. Representative images (b) and statistical quantification (c) of irradiation induced cell death analyzed by FACS. d Western blotting analysis of the expression of Caspase-3 and cleaved Caspase-3 in irradiated cells. e Western blotting analysis p-ATM, total ATM, p-CHK2, total CHK2, p53, p21 and γ-H2AX in indicated cells treated with or without irradiation. α-Tubulin and GAPDH served as loading control. Error bars represent SD from 3 independent experiments. *p < 0.05