Table 4.
Other ERV Insertions
| Mutation | MGI IDa | Strain of Origin | ERV, Location, Orientationb | Mutational mechanisms or effects | References |
|---|---|---|---|---|---|
| Agtpbp1 pcd-2J | 1856536 | SM/J | ERV-β2/ETnERV3, Intron 13, + | Greatly reduced full length gene transcripts | [264] |
| Etn2 Sd | 1857746 | Danforth’s posterior duplication stock | ERVβ-2/ETnERV3, 12 kb upstream, + | Overexpression of Ptf1a and two neighboring genes, acts as an enhancer | [140–142] |
| Nox3 het | 1856606 | GL/Le | Presumed ERVβ-2/ETnERV3, Intron 12, + | Transcripts show aberrant splicing from Nox3 into retroviral element | [139, 265] |
| Prph2 Rd2 | 1856523 | O20/A | ERVβ-2/ETnERV3, Exon 2, − | Transcripts contain entire ERV, coding sequence disruption | [266, 267] |
| Ednrb s | 1856148 | Fancy mice | ERVβ-4, Intron 1, + | Aberrant splicing and premature polyadenylation | [268] |
| a | 1855937 | Fancy mice | VL30, Intron 1, −; ERVβ-4 within VL30, + | Smaller gene mRNA and levels 8 fold lower than in wild-type. Aberrant splicing and premature termination within the ERVβ-4 |
[22, 143] |
| Dock7 m | 1856946 | JAX Dilute Brown | MERV-L, Exon 18, + | Frameshift and premature termination | [269, 270] |
| Fgf5 go-moja | 6147688 | ICR | Partial MTA MaLR, Intron 2, − | 498 bp insertion is combined with 9.3 kb deletion of exon 3 and flanking sequence, no detectable transcripts | [158] |
| Grm1 crv4 | 3664783 | BALB/c/Pas | MERV-L solitary LTR, intron 4, + | Aberrant splicing and premature termination, transcripts contain LTR sequence | [271] |
| Npc1 m1N | 1857409 | BALB/c | Partial MERV-L, Exon 9 | 824 bp partial and rearranged MERV-L combined with 703 bp deletion. Transcripts contain MERV-L sequence, decreased expression, premature truncation | [159] |
aID number in Mouse Genome Informatics (MGI) database
b- = antisense, + = sense,? = orientation unknown