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. 2019 Apr 16;9:9. doi: 10.1186/s13395-019-0194-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — PCA and heat map of DEGs of muscle samples from ICU patients and healthy controls. a PCA of TA skeletal muscle samples from healthy control subjects and ICU patients with CIM using all genes (RPKM log2 transformed and mean centered) b Heat map of top 1266 DEGs between ICU patients with CIM and healthy control muscle samples (independent group t test p < 0.05 and fold difference ≥ 3). RPKM of each gene was normalized against the mean of healthy controls and followed by log2 transformation