Chisholm 2005.
Methods | Single‐centre CCT conducted in the United Kingdom during the 2001‐2002 and 2002‐2003 influenza seasons | |
Participants | 59 children with various non‐leukaemic malignancies who were receiving chemotherapy and 10 children with various non‐leukaemic malignancies who had been off chemotherapy for 4 weeks to 6 months. Age between 6 months and 16 years | |
Interventions | Trivalent inactivated split virion (Aventis Pasteur MSD) subcutaneously, with the following strains in 2001‐2002: A/New Cal/20/99 (H1N1), A/Panama/2007/99 (H3N2), B/Sichuan/379/99. In 2002‐2003, B/Hong Kong/331/01 replaced B/Sichuan/379/99 Age‐dependent schedule: < 4 years: two doses of 0.25 ml 3 to 4 weeks apart. 4 to 12 years: two doses of 0.5 ml 3 to 4 weeks apart. > 13 years: one dose of 0.5 ml. Previously immunised children: one dose 0.25 ml (< 4 years) or 0.5 ml (> 4 years) |
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Outcomes | (1) Seroconversion (defined as four‐fold rise in antibody titre) after vaccination (2) Development of protective HI titre (≥ 32) post‐vaccination (3) Pre‐ and post‐vaccination GMT (4) Adverse reactions | |
Notes | Results of children off chemotherapy stated only as "no impact" in subgroup analysis; no separate results were presented. Authors were contacted for additional information on the results of children off chemotherapy, and these results were obtained |