Gross 1978.

Methods	Multi‐centre CCT conducted in New York, USA Response to influenza vaccine in children with cancer who were receiving chemotherapy was compared with that of children with cancer off chemotherapy
Participants	68 children with various malignancies who were receiving chemotherapy and 74 children with various malignancies who had been off chemotherapy for at least the last 1 month. Mean age 10 years (range 3 to 18 years)
Interventions	Various influenza vaccines were used: (1) split‐product vaccine (Parke‐Davis) containing 400 CCA units of A/NJ/8/76 and 400 CCA of A/Vic/3/75 per dose, (2) whole virus vaccine (Merrell‐National vaccine) containing 100 CCA units of A/NJ/8/76 and 100 CCA units of A/Vic/3/75, (3) whole virus vaccine (Merck Sharp & Dohme vaccine) containing 50 CCA units of A/NJ/8/76 and 50 CCA units of A/Vic/3/75 Subjects received two injections with a 1‐month interval between doses. 3‐ to 5‐year‐olds received half the amount given to older children
Outcomes	(1) Pre‐ and post‐vaccination GMT (2) Development of protective HI titre (≥ 40) post‐vaccination (3) Adverse reactions
Notes