Gross 1978.
Methods | Multi‐centre CCT conducted in New York, USA Response to influenza vaccine in children with cancer who were receiving chemotherapy was compared with that of children with cancer off chemotherapy |
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Participants | 68 children with various malignancies who were receiving chemotherapy and 74 children with various malignancies who had been off chemotherapy for at least the last 1 month. Mean age 10 years (range 3 to 18 years) | |
Interventions | Various influenza vaccines were used: (1) split‐product vaccine (Parke‐Davis) containing 400 CCA units of A/NJ/8/76 and 400 CCA of A/Vic/3/75 per dose, (2) whole virus vaccine (Merrell‐National vaccine) containing 100 CCA units of A/NJ/8/76 and 100 CCA units of A/Vic/3/75, (3) whole virus vaccine (Merck Sharp & Dohme vaccine) containing 50 CCA units of A/NJ/8/76 and 50 CCA units of A/Vic/3/75 Subjects received two injections with a 1‐month interval between doses. 3‐ to 5‐year‐olds received half the amount given to older children |
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Outcomes | (1) Pre‐ and post‐vaccination GMT (2) Development of protective HI titre (≥ 40) post‐vaccination (3) Adverse reactions | |
Notes |