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. 2013 Aug 1;2013(8):CD006484. doi: 10.1002/14651858.CD006484.pub3

Hsieh 2002a.

Methods RCT conducted in Taiwan during the 2000‐2001 influenza season
Children with ALL were randomly assigned to one of two vaccination protocols
Participants 25 children with ALL receiving maintenance chemotherapy. Mean age 7.3 years
Interventions Trivalent inactivated split virus (Vaxigrip) influenza vaccine A/Panama/2007/99 (H3N2), A/New Caledonis/20/99 (H1N1), B/Yamanashi/166/98. Participants received two 0.5 ml doses containing 15 µg hemagglutinin, 4 weeks apart
Of the children with ALL, n = 14 received dose 1 of vaccine and reinduction chemotherapy on the same day; 4 weeks later, they received dose 2. N = 11 received dose 1 alone, 4 weeks later, they received dose 2 + reinduction chemotherapy on the same day
Outcomes (1) GMT pre‐ and post‐vaccination
 (2) Development of protective HI titre (≥ 40) post‐vaccination
 (3) Four‐fold rise in antibody titre after vaccination
 (4) Adverse reactions
Notes Additional information on randomisation methods was requested and not obtained