Hsieh 2002b.
Methods | CCT conducted in Taiwan during the 2000‐2001 influenza season Response to influenza vaccine in children with ALL is compared with that of children with asthma |
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Participants | 30 children with asthma in remission (no inhaled steroids within 2 weeks or oral steroids within 1 month before influenza vaccination), mean age 6.5 years, compared with 25 children with ALL receiving maintenance chemotherapy, mean age 7.3 years | |
Interventions | Trivalent inactivated split virus (Vaxigrip) influenza vaccine A/Panama/2007/99 (H3N2), A/New Caledonis/20/99 (H1N1), B/Yamanashi/166/98. Participants received two 0.5 ml doses containing 15 µg hemagglutinin, 4 weeks apart | |
Outcomes | (1) GMT pre‐ and post‐vaccination (2) Development of protective HI titre (≥ 40) post‐vaccination (3) Four‐fold rise in antibody titre after vaccination (4) Adverse reactions | |
Notes | Dosage: > 8 years received 1 dose, and children younger than 8 received two doses of vaccine |