Shahgholi 2010.
Methods | Single‐centre controlled clinical trial conducted in Iran during the 2007‐2008 influenza season. Responses of children with ALL on maintenance therapy to influenza vaccine were compared with those of healthy siblings | |
Participants | 32 children aged 1 to 18 years with ALL in first remission on maintenance chemotherapy. Controls were 30 healthy siblings, similar in age and gender distribution Previously vaccinated children were excluded from the study |
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Interventions | Trivalent inactivated influenza vaccine (Influvac), containing the following strains: A/Solomon Islands 3/2006 (H1N1), A/Wisconsin/67/2005 (H3N2), B/Malaysia/2506/2004. Participants received two doses of 0.25 ml 3 to 4 weeks apart for children < 36 months of age, two doses of 0.5 ml for children 36 months to 13 years and one dose of 0.5 ml for children aged > 13 years | |
Outcomes | (1) Development of protective HI titre (> 40) post‐vaccination; this is considered seroconversion (defined as four‐fold rise in antibody titre) after vaccination (3) Pre‐ and post‐vaccination GMT (4) Adverse reactions |
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Notes | Data on adverse reactions were available for 35 of 62 participants (56%) |