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. 2019 Apr 15;19:353. doi: 10.1186/s12885-019-5569-5

Fig. 1.

Fig. 1

PRISMA Chart. PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Note: Some studies were reported in multiple publications; in such cases, the main study report was classed as the “primary” publication, and any other articles reporting on the same trial were classed as “secondary reports.” Therefore, the primary reports are all unique trials