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. 2019 Apr 15;14:64. doi: 10.1186/s13014-019-1268-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — MCF-7 RR and ZR-751 RR cell lines show increased expression of vimentin, N-cadherin and SNAIL with the partial down regulation of E-cadherin. a H&E staining of parental and RR cell lines detailing their morphological differences. b IHC staining of EMT markers (vimentin, N-cadherin, SNAIL and E-cadherin) in MCF-7 and MDA-MB-231 parental and RR MTS and cells. c Heatmap showing log2 mean-centered gene expression profiles in respect of a published cancer cell EMT-signature [23]; red = higher expression, green = lower. The gene list and the order in which they appear in the heatmap are shown in Additional file 6: Table S3