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Carbohydrate metabolism is improved in the lean or obese Siah2KO female mice. a Glucose tolerance and b insulin tolerance testing were carried out at 12 weeks on the LFD or HFD. c Fasting blood glucose, d insulin, e triglycerides, and f free fatty acid levels were assayed after 16 weeks on the LFD or HFD in the female mice. Statistical significance was determined using repeated measures ANOVA in a and b and two-tailed, unpaired t test in c–f
