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. 2019 Apr 15;10:19. doi: 10.1186/s13293-019-0233-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Siah2 regulates expression of markers of thermogenesis in female, but not male brown adipose tissue. Gene expression of markers of a lipid metabolism, b mitochondrial function, c thermogenesis, and d inflammation were assayed in brown adipose tissue of wild-type (WT) and Siah2KO (KO) male (M) and female(F) mice after 16 weeks on the HFD using real-time qRT-PCR. e Serum leptin levels were assayed in male and female wild-type (WT) and Siah2KO (KO) at 16 weeks on the HFD. Statistical significance was determined using a two-tailed, unpaired t test, a, p < 0.05, b, p < 0.01, c, p < 0.001; Siah2KO compared to wild-type within the same sex