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. 2019 Feb 19;10(4):661–665. doi: 10.1021/acsmedchemlett.9b00023

Scheme 1. Synthetic Route to Compounds 1–6.

Scheme 1

Reagents and conditions: (a) 2.8 M SnCl2 in 37% HCl, EtOH, 0 °C, 24 h; (b) appropriate aroyl chloride, Et3N, dry DCM, 0 °C, 2–24 h; (c) diethyl oxalate, EtONa, dry THF, N2 atmosphere, rt, 3–5 h; (d) 0.7 M LiOH, THF/MeOH, rt, 6–8 h.