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Comparison of the actinobacterial 20S proteasome-associated regulator complexes.
| Mpa/ARC | Bpa | Cpa | |
|---|---|---|---|
| ATPase activity | Yes | No | Yes |
| Oligomeric state | Hexamer | Dodecamer | Hexamer |
| Relevant stress condition | Persistence, nitrogen starvation, DNA damage | Heat shock | Carbon starvation |
| 20S core interaction | GxYx | GxYx | ? |
| Substrate recruitment requirements | Pupylation, N-terminal coiled-coil of Mpa | Disorder | N-domain? Adapter proteins? |
| Known/well-studied substrates | e.g., Mpa, PanB, FabD, RecA, LOG | HspR | ? |
