Table 1.
Demographic and clinical characteristics of SP patients with or without ARDS development.
| Parameters | SP with ARDS development | P value | |
|---|---|---|---|
| Yes (n = 37) | No (n = 108) | ||
| Age (years) | 61.3 ± 10.4 | 56.4 ± 9.8 | 0.011 |
| Gender (n, %) | 0.12 | ||
| Male | 23 (62.2%) | 51 (47.2%) | |
| Female | 14 (37.8%) | 57 (52.8%) | |
| Current smokers (n, %) | 12 (32.4%) | 23 (21.3%) | 0.17 |
| Clinical scores | |||
| APACHE II | 16.7 ± 5.1 | 16.5 ± 4.7 | 0.83 |
| SOFA | 4.4 ± 1.9 | 5.2 ± 2.1 | 0.043 |
| LIS | 2.5 ± 0.7 | 2.2 ± 0.6 | 0.013 |
| Comorbidities | |||
| Diabetes | 7 (18.9%) | 27 (25.0%) | 0.45 |
| Metabolic diseases | 2 (5.4%) | 8 (7.4%) | 0.68 |
| Renal diseases | 7 (18.9%) | 21 (19.4%) | 0.94 |
| Cardiovascular diseases | 6 (16.2%) | 17 (15.7%) | 0.95 |
| Sepsis (%) | 19 (51.4%) | 43 (39.8%) | 0.22 |
| Body temperature (°C) | 37.5 ± 0.9 | 37.1 ± 0.8 | 0.012 |
| Respiratory rate (bpm) | 24.3 ± 7.8 | 23.8 ± 8.4 | 0.75 |
| Heart rate (bpm) | 112.4 ± 19.9 | 103.4 ± 17.8 | 0.011 |
| SBP (mmHg) | 110.1 ± 20.1 | 119.8 ± 24.3 | 0.031 |
| DBP (mmHg) | 68.4 ± 15.9 | 70.4 ± 16.1 | 0.51 |
| SpO2 (%) | 94.1 ± 5.5 | 96.2 ± 4.8 | 0.029 |
| Pleural effusion (%) | 23 (62.2%) | 78 (72.2%) | 0.25 |
| Treatment strategies during the overall ICU stay (%) | |||
| Corticosteroids | 21 (56.8%) | 75 (69.4%) | 0.16 |
| Blood product transfusion | 6 (16.2%) | 11 (10.2%) | 0.33 |
| MV | 36 (97.3%) | 100 (92.6%) | 0.31 |
SP, severe pneumonia; ARDS, acute respiratory distress syndrome; APACH, acute physiology and chronic health evaluation; SOFA, sequential organ failure assessment; LIS, lung injury score; SBP, systolic blood pressure; DBP, diastolic blood pressure; SpO2, oxygen saturation of pulse oximetry; MV, mechanical ventilation. P values were calculated by Student's t-test, Mann–Whitney U-test, chi-squared test, or Fisher's exact test. ∗P < 0.05.