Table 6.

Clinical outcomes and heart rate as continuous variable and bisection.

Outcomes	HR (95% CI)	P values	Adjusted HR (95% CI)	P values
Total population
ACM
Heart rate ≥80 vs. <80 beats/min	1.894 (1.513–2.370)	<0.001	1.905 (1.507–2.408)	<0.001
Heart rate higher by 1 beat/min	1.027 (1.018–1.037)	<0.001	1.027 (1.018–1.037)	<0.001
CM
Heart rate ≥80 vs. <80 beats/min	2.152 (1.680–2.757)	<0.001	2.170 (1.672–2.815)	<0.001
Heart rate higher by 1 beat/min	1.030 (1.020–1.040)	<0.001	1.030 (1.020–1.041)	<0.001
MACEs
Heart rate ≥80 vs. <80 beats/min	1.391 (1.203–1.607)	<0.001	1.373 (1.181–1.596)	<0.001
Heart rate higher by 1 beat/min	1.017 (1.011–1.023)	<0.001	1.015 (1.009–1.022)	<0.001
ACS patients
ACM
Heart rate ≥80 vs. <80 beats/min	2.668 (1.726–4.121)	<0.001	2.689 (1.661–4.352)	<0.001
Heart rate higher by 1 beat/min	1.025 (1.010–1.039)	<0.001	1.026 (1.010–1.042)	0.001
CM
Heart rate ≥80 vs. <80 beats/min	2.993 (1.876–4.778)	<0.001	3.195 (1.894–5.390)	<0.001
Heart rate higher by 1 beat/min	1.026 (1.010–1.042)	0.001	1.029 (1.011–1.046)	0.001
MACEs
Heart rate ≥80 vs. <80 beats/min	1.686 (1.283–2.215)	<0.001	1.704 (1.283–2.263)	<0.001
Heart rate higher by 1 beat/min	1.013 (1.004–1.022)	0.004	1.012 (1.003–1.022)	0.013
Stable CAD patients
ACM
Heart rate ≥80 vs. <80 beats/min	1.570 (1.206–2.044)	0.001	1.573 (1.198–2.066)	0.001
Heart rate higher by 1 beat/min	1.030 (1.018–1.043)	<0.001	1.030 (1.017–1.42)	<0.001
CM
Heart rate ≥80 vs. <80 beats/min	1.809 (1.347–2.431)	<0.001	1.819 (1.339–2.471)	<0.001
Heart rate higher by 1 beat/min	1.035 (1.021–1.049)	<0.001	1.035 (1.021–1.049)	<0.001
MACEs
Heart rate ≥80 vs. <80 beats/min	1.273 (1.070–1.515)	0.007	1.248 (1.051–1.483)	0.011
Heart rate higher by 1 beat/min	1.019 (1.011–1.028)	<0.001	1.019 (1.010–1.028)	<0.001