Table 4.
Relationship between rs13333226 polymorphisms in the UMOD gene and clinical and demographic features in first-degree relatives.
| rs13333226 | AA | AG | GG | p-value# |
|---|---|---|---|---|
| N (%) | 22 | 17 | 11 | |
| Gender (M/F) | 8/14 | 6/11 | 3/8 | 0.865∗ |
| Age, years | 34 (22-53) | 29 (20-51) | 25 (22-41) | 0.684 |
| Systolic BP, mmHg | 126 (120-139) | 135 (119-149) | 128 (120-132) | 0.662 |
| Diastolic BP, mmHg | 76 (72-87) | 75 (72-89) | 76 (69-82) | 0.682 |
| Serum creatinine, µmol/L | 77 (64-84) | 76 (66-86) | 65 (62-92) | 0.601 |
| CKD-EPI eGFR, ml/min per 1.73 m2 | 118 (82-138) | 105 (91-137) | 139 (87-143) | 0.398 |
| Uric acid, mmol/L | 0.3 (0.3-0.4) | 0.3 (0.3-0.4) | 0.3 (0.2-0.3) | 0.752 |
| Urine ACR mg/mmol | 1.2 (0.4-2.9) | 0.4 (0.0-2.2) | 2.9 (1.4-4.2) | 0.225 |
| Log Uromodulin concentration (µg/ml), mean ±SD | 1.0 ± 1.1 | 0.8 ± 1.5 | 1.1 ± 1.0 | 0.874$ |
Data given as median (interquartile range) unless specified
P values- #Kruskal-Wallis unless specified; ∗Pearson's chi square; $ANOVA tests
Abbreviations: BP, blood pressure; eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; ACR, albumin: creatinine ratio.