Table 2.
Univariate and multivariate analysis of prognostic factors for overall survival.
| Characteristics | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Patient factors | ||||
| Age (years) | 1.028 [0.994, 1.063] | 0.110 | ||
| Male sex | 1.426 [0.500, 4.069] | 0.507 | ||
| Hepatitis B | 1.462 [0.737,2.898] | 0.276 | ||
| Child Pugh B | 1.806 [0.692, 4.714] | 0.227 | ||
| Laboratory data | ||||
| ICG>15 | 1.353 [0.470, 3.891] | 0.575 | ||
| Creatinine | 0.999 [0.993,1.004] | 0.816 | ||
| Surgical factors | ||||
| Major surgery | 1.733 [0.859,3.496] | 0.125 | ||
| Operation time > 350min | 2.156 [1.080, 4.301] | 0.029 | 1.834 [0.875, 3.842] | 0.108 |
| EBL>500ml | 5.400 [1.644, 17.739] | 0.005 | 5.286 [1.577,17.712] | 0.007 |
| Tumor factors | ||||
| AFP>400 | 1.906 [0.820, 4.431] | 0.134 | ||
| Tumor size>5cm | 2.396 [1.174, 4.888] | 0.016 | 1.480 [0.685, 3.197] | 0.318 |
| Multiple tumors | 1.805 [0.855,3.809] | 0.121 | ||
| R1 resection | 2.817 [1.149, 6.906] | 0.024 | 3.112 [1.251, 7.443] | 0.015 |
| Inflammatory indices | ||||
| PLR ≥155 | 2.000 [1.007, 3.973] | 0.033 | ||
| NLR ≥ 2.7 | 2.175 [1.069, 4.425] | 0.032 | ||
| PLR ≥155 and NLR ≥ 2.7 | 2.889 [1.342,6.222] | 0.007 | 2.496 [1.156,5.389] | 0.020 |
HR: hazard ratio, CI: confidence interval, ICG: indocyanine green, EBL: estimated blood loss, AFP: alpha-fetoprotein, NLR: neutrophil-to-lymphocyte ratio, and PLR: platelet-to-lymphocyte ratio.