Table 3.
Univariate and multivariate analysis of prognostic factors of recurrence free survival.
| Characteristics | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Patient factors | ||||
| Age (years) | 1.012 [0.991, 1.034] | 0.266 | ||
| Male sex | 1.674 [0.796, 3.518] | 0.174 | ||
| Hepatitis B | 1.072 [0.661, 1.737] | 0.778 | ||
| Child Pugh B | 1.692 [0.833, 3.440] | 0.146 | ||
| Laboratory data | ||||
| Creatinine | 0.998 [0.993, 1.003] | 0.461 | ||
| ICG>15 | 1.164 [0.570, 2.373] | 0.677 | ||
| Surgical factors | ||||
| Major surgery | 1.128 [0.696, 1.828] | 0.626 | ||
| Operation time > 350min | 1.474 [0.890, 2.439] | 0.132 | ||
| EBL>500ml | 1.788 [1.026, 3.113] | 0.040 | 1.781 [1.017,3.120] | 0.043 |
| Tumor factors | ||||
| AFP >400 | 1.331 [0.695, 2.549] | 0.388 | ||
| Size>5cm | 1.498 [0.926, 2.423] | 0.100 | 0.909 [0.522,1.581] | 0.735 |
| Multiple tumors | 1.293 [0.734,2.276] | 0.374 | ||
| R1 resection | 2.492 [1.215, 5.109] | 0.013 | 2.340 [1.093,5.010] | 0.029 |
| Inflammatory indices | ||||
| PLR ≥155 | 1.717 [1.047, 2.814] | 0.032 | ||
| NLR ≥ 2.7 | 1.751 [1.078, 2.845] | 0.032 | ||
| PLR ≥155 and NLR ≥ 2.7 | 2.115 [1.294,3.455] | 0.003 | 1.917 [1.161,3.166] | 0.011 |
HR: hazard ratio, CI: confidence interval, ICG: indocyanine green, EBL: estimated blood loss, AFP: alpha-fetoprotein, NLR: neutrophil-to-lymphocyte ratio, and PLR: platelet-to-lymphocyte ratio.