Table 4.
Clinicopathological characteristics of patients undergoing curative hepatectomy for HCC.
| Clinical variables | NLR-PLR 0 | NLR-PLR 1 | NLR-PLR 2 | p |
|---|---|---|---|---|
| n = 64 (49%) | n = 32 (24%) | n = 36 (27%) | ||
| Patient factors | ||||
| Male (n, %) | 55 (85.9%) | 29 (90.6%) | 32 (88.9%) | 0.78 |
| Age(years; mean ± SD) | 64.5±8.9 | 67.8±8.8 | 63.9±12.6 | 0.24 |
| Hepatitis B (n, %) | 39 (60.9.%) | 18 (56.2%) | 18 (50.0%) | 0.57 |
| Child-Pugh Class B (n, %) | 1 (1.6) | 3 (9.4%) | 9 (25.0%) | <0.01 |
|
| ||||
| Laboratory data | ||||
| ICG>15 (n, %) | 21 (32.8%) | 7 (21.9%) | 2 (5.6%) | 0.01 |
| Creatinine (mean ± SD) | 104±133 | 95±43 | 87±101 | 0.69 |
|
| ||||
| Surgical factors | ||||
| Major hepatectomy (n, %) | 26 (40.6%) | 12 (37.5%) | 23 (63.9%) | 0.04 |
| Operation time >350min (n, %) | 21 (32.8%) | 7 (21.9%) | 15 (41.7%) | 0.22 |
| EBL >500ml (n, %) | 37 (57.8%) | 19(59.4%) | 25 (69.4%) | 0.50 |
|
| ||||
| Tumor factors | ||||
| AFP >400ug/L (n, %) | 11 (20.8%) | 6 (18.8%) | 1 (2.7%) | 0.08 |
| Tumor size >5 (n, %) | 20 (31.2%) | 12 (37.5%) | 28(77.8%) | <0.01 |
| Multiple tumors (n, %) | 12 (18.8%) | 10 (31.2%) | 8 (22.2%) | 0.38 |
| R1 resection (n, %) | 4 (6.2%) | 2 (6.2%) | 7 (19.4%) | 0.08 |
|
| ||||
| Postoperative factors | ||||
| Wound infection | 2 (3.1%) | 3 (9.4%) | 1 (2.8%) | 0.32 |
| Pneumonia | 10 (15.6%) | 5 (15.6%) | 7 (19.4%) | 0.87 |
| UTI | 3 (4.7%) | 3 (9.4%) | 1 (2.8%) | 0.46 |
| Bile leak | 0 (0) | 0 (0) | 2 (5.6%) | 0.07 |
| Intra-abdominal collection | 2 (3.1%) | 0 (0) | 2 (5.6%) | 0.41 |
| Liver failure | 4 (6.2%) | 3 (9.4%) | 4 (11.1%) | 0.68 |
|
| ||||
| Follow-up | ||||
| 30-day mortality | 2 (3.1%) | 1 (3.1%) | 0 (0) | 0.52 |
| LOS (days, mean ± SD) | 11.2±11.6 | 13.4±20.6 | 19.7± 26.2 | 0.22 |
| OS (months, median [IQR]) | 26.5 (11-48) | 19.5 (5-36) | 24.5 (7-37) | 0.02 |
| RFS (months, median [IQR]) | 20 (7-40.5) | 12 (5-25) | 14.5 (4-28) | 0.02 |
NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; ICG: indocyanine green; EBL: estimated blood loss; AFP: a-fetoprotein; UTI: urinary tract infection; LOS: length of stay; OS: overall survival; RFS: recurrence free survival; IQR: interquartile range; SD: standard derivation.