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. Author manuscript; available in PMC: 2019 Apr 16.
Published in final edited form as: J Neurol Neurosurg Psychiatry. 2018 Nov 22;90(3):294–301. doi: 10.1136/jnnp-2018-318795

Figure 3.

Figure 3.

Longitudinal changes in motor cortex tNAA/mIns are related to progression of upper limb function. Patients who had declining ALSFRS-R upper limb scores over the follow-up period experienced decreasing tNAA/mIns over the same time window (both p < 0.01). In contrast, patients who had stable ALSFRS-R upper limb scores showed no change in tNAA/mIns over time. Analyses were performed on data from participants who completed two or three visits. P-values are from a test of the mean slope against no change over time.