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. Author manuscript; available in PMC: 2019 Apr 16.
Published in final edited form as: J Neurol Neurosurg Psychiatry. 2018 Nov 22;90(3):294–301. doi: 10.1136/jnnp-2018-318795

Figure 4.

Figure 4.

Longitudinal changes in pons Glx levels are related to progression of bulbar function. Patients who had declining ALSFRS-R bulbar scores over the follow-up period experienced increasing Glx levels in the pons over the same time window (p < 0.0001). In contrast, patients who had stable ALSFRS-R bulbar scores showed no change in pons Glx levels over time. Analyses were performed on data from participants who completed two or three visits. P-values are from a test of the mean slope against no change over time.