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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Cell Calcium. 2018 Dec 6;77:58–67. doi: 10.1016/j.ceca.2018.12.003

Figure 4: STIM1-mediated control of Ca2+ entry and clearance.

Figure 4:

ER Ca2+ depletion causes STIM1 to oligomerize and extend towards the PM to activate Ca2+ entry via Orai channels. STIM1 also interacts with PMCA through its serine/threonine-rich domain causing decreased function.