Table 2.
Prothrombotic Predisposition for Portal Vein Thrombosis
| Condition | Diagnostic Features |
|---|---|
| Myeloproliferative disease | V617F JAK2 mutation Dystrophic megakaryocytes at bone marrow biopsy |
| Paroxysmal nocturnal hemoglobinuria | CD55 and CD59 deficiency in flow cytometry of peripheral blood cells Ham‐Dacie and sucrose tests |
| Antiphospholipid syndrome | Idiopathic venous or arterial thrombosis, repeated miscarriage with high anticardiolipin antibodies or lupus anticoagulant or anti‐beta2 glycoprotein 1 |
| Factor V Leiden | Increased protein C resistance Factor V mutation: R605Q |
| Factor II gene mutation | G20210A mutation |
| Inherited antithrombin deficiency | Decreased antithrombin level and normal prothrombin level |
| Inherited protein C deficiency | Decreased protein C level and normal prothrombin levels |
| Inherited protein S deficiency | Decreased protein S level and normal prothrombin levels |
| Hyperhomocysteinemia | Increased serum homocysteine level MTHFR mutation |