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. 2019 Apr 9;10:332. doi: 10.3389/fneur.2019.00332

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Copyright © 2019 Laso-García, Diekhorst, Gómez-de Frutos, Otero-Ortega, Fuentes, Ruiz-Ares, Díez-Tejedor and Gutiérrez-Fernández.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative evolution of the evaluation of the effect of various comorbidities in animal models of stroke as well as in clinical research. An advanced search was performed in PubMed in December 2018 to find, for each year of publication, all articles using the text word stroke with the given term as text word: age or aging; hypertension or hypertensive or high blood pressure; diabetes or diabetes mellitus; hyperglycemia or hyperglycemic or high blood sugar or high glucose levels; or obesity or overweight. Year of final publication (and not advanced online date) of articles in English (and not other languages) was taken into account. Manual elimination of articles describing a non-comorbid stroke association were excluded.