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. 2019 Apr 9;10:725. doi: 10.3389/fimmu.2019.00725

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Copyright © 2019 Saxena, Sabado, La Mar, Mohri, Salazar, Dong, Correa Da Rosa, Markowitz, Bhardwaj and Miller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Markers of immune activation and exhaustion on CD4⁺ and CD8⁺ T cells following Poly-ICLC administration. In order to monitor for the secondary induction of generalized immune activation following Poly-ICLC administration, surface expression of CD38, HLA-DR, PD-1, and CTLA-4 was evaluated at each time point via flowcytometry on subjects'; (A) CD8⁺ T cells and (B) CD4⁺ T cells. No longitudinal changes were found to be statistically significant following Poly-ICLC administration with the exception of transient upregulation of CD38 on CD8⁺ T cells at Day 4. ^*p < 0.001.