FIGURE 5.

Western blot confirmation of OXTR protein upregulation in VaD frontal cortex. Membrane fractions of the same tissue blocks of frontal cortex were used to detect protein levels of OXTR. (A) Representative western blot showing OXTR and calnexin immunoreactivity in CTL, VaD, and AD cases. (B) Quantitative analysis revealed that protein levels were significantly different among the 3 diagnostic groups (Kruskal-Wallis test [H = 7.426, p = 0.03]). OXTR levels in VaD were significantly different than CTL (Dunn's multiple comparison test [mean rank = −10.63, multiplicity-adjusted p = 0.033]), with intermediate but nonsignificant levels detected in AD. *p < 0.05. Samples were run as technical replicates with means used for statistical analysis.