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. 2018 Oct 26;74(2):132–140. doi: 10.1136/thoraxjnl-2018-211929

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Discriminative dimension reduction (DDR) graph of GSE93606 IPF peripheral blood RNA data using module ME1 (cilia) gene list. K-means clustering was used to separate samples into two groups (yellow and purple). (B) Heatmap of gene expression sorted by DDR score. (C) Kaplan-Meier curves for groups defined by DDR k-means clustering of ME1 genes in peripheral blood dataset. Multivariate Cox’s proportional hazard modelling of module groups, FVC, sex and age showed ME1 had significant association with survival (p=0.0097). IPF, idiopathic pulmonary fibrosis; ME, module eigengene.