Table 1.
Description of the population samples, and differences between them.
| Total sample | Cohort |
||||
|---|---|---|---|---|---|
| Budapest | Manchester | Comparison (p-Value) | |||
| Population size | (N) | 2193 | 902 | 1291 | |
| Demographics | |||||
| Gender | (% Male) | 30.10% | 29.79% | 30.31% | 0.792 |
| Age | (Mean ± SEM; range) | 32.89 ± 0.220 | 31.23 ± 0.350 | 34.03 ± 0.279 | <0.0001 |
| (18–60) | (18–60) | (18–60) | |||
| Stress type scores (within the last year) | |||||
| RLE-relationship | (Mean ± SEM) | 0.13 ± 0.008 | 0.13 ± 0.013 | 0.14 ± 0.010 | 0.536 |
| RLE-financial | (Mean ± SEM) | 0.23 ± 0.011 | 0.15 ± 0.014 | 0.28 ± 0.016 | <0.0001 |
| RLE-illness/personal | (Mean ± SEM) | 0.37 ± 0.013 | 0.33 ± 0.020 | 0.39 ± 0.017 | 0.028 |
| RLE-social | (Mean ± SEM) | 0.41 ± 0.013 | 0.41 ± 0.021 | 0.40 ± 0.017 | 0.727 |
| Recent depression/anxiety | |||||
| Current BSI depression score | (Mean ± SEM) | 0.87 ± 0.019 | 0.57 ± 0.023 | 1.07 ± 0.028 | <0.0001 |
| Current BSI anxiety score | (Mean ± SEM) | 0.89 ± 0.019 | 0.70 ± 0.023 | 1.01 ± 0.027 | <0.0001 |
| Genotype | |||||
| CNR1 rs7766029 | 0.011 | ||||
| CC | (N) | 594 | 214 | 380 | |
| TC | (N) | 1094 | 466 | 628 | |
| TT | (N) | 505 | 222 | 283 | |
| MAF (minor allele) | 0.48 (T) | 0.50 (C) | 0.46 (T) | ||
| GABRA6 rs3219151 | 0.791 | ||||
| CC | (N) | 434 | 183 | 251 | |
| TC | (N) | 1053 | 424 | 629 | |
| TT | (N) | 719 | 295 | 424 | |
| MAF (minor allele) | 0.44 (C) | 0.44 (C) | 0.43 (C) | ||
BSI, Brief Symptom Inventory; RLE, number of recent negative life events (within the last year); RLE-financial, financial difficulties; RLE-illness/personal, illness, and personal problems; RLE-relationship, intimate relationship problems; RLE-social, social network disturbances; SEM, standard error of mean; MAF, minor allele frequency; comparison, p-Value of the t-test or Pearson χ2 test, as appropriate. Significant p-values (< 0.05) are marked in bold.