Table 3.

Interactions of number of recent negative life events and CNR1 (rs7766029) or GABRA6 (rs3219151) polymorphisms on BSI anxiety and BSI depression scores as the outcome in the combined Budapest + Manchester sample.

	CNR1 (rs7766029)					GABRA6 (rs3219151)
Stress type (within the last year)	β	S.E.	STAT	P	FDR Q	β	S.E.	STAT	P	FDR Q
BSI anxiety score
Interaction with RLE – relationship	0.006	0.0679	0.084	0.933	0.538	-0.045	0.0720	-0.623	0.533	0.424
Interaction with RLE – financial	0.140	0.0498	2.815	0.005	0.022	-0.077	0.0506	-1.525	0.127	0.172
Interaction with RLE – illness/personal	0.007	0.0433	0.152	0.880	0.538	-0.059	0.0423	-1.392	0.164	0.172
Interaction with RLE – social	-0.007	0.0435	-0.168	0.867	0.538	-0.096	0.0415	-2.316	0.021	0.045
BSI depression score
Interaction with RLE – relationship	-0.037	0.0683	-0.535	0.593	0.432	-0.100	0.0724	-1.379	0.168	0.172
Interaction with RLE – financial	0.134	0.0503	2.664	0.008	0.023	-0.057	0.0512	-1.112	0.266	0.233
Interaction with RLE – illness/personal	0.073	0.0436	1.682	0.093	0.162	-0.125	0.0426	-2.928	0.003	0.022
Interaction with RLE – social	0.001	0.0440	0.021	0.984	0.538	-0.057	0.0420	-1.349	0.177	0.172

BSI, Brief Symptom Inventory; FDR, false discovery rate; S.E., standard error of beta; STAT, coefficient t-statistic; RLE, number of recent negative life events (within the last year); RLE – financial, financial difficulties; RLE-illness/personal, recent illness and personal problems; RLE – relationship, intimate relationship problems; RLE – social, social network disturbances. We tested additive models on a combined population sample of Budapest and Manchester. The effect allele is T in case of CNR1 rs7766029, and C in case of GABRA6 rs3219151. All significant P-values (marked in bold) survived correction for multiple testing (P ≤ 0.05, FDR Q ≤ 0.05).