Table 4.
Re-analysis of data split according to study site in the Budapest and Manchester subsamples.
| Budapest subsample |
Manchester subsample |
|||||||
|---|---|---|---|---|---|---|---|---|
| Gene-environment interaction | β | S.E. | STAT | P | β | S.E. | STAT | P |
| BSI anxiety score | ||||||||
| CNR1 interaction with RLE – financial | 0.127 | 0.0794 | 1.601 | 0.110 | 0.143 | 0.0652 | 2.188 | 0.029 |
| GABRA6 interaction with RLE – social | -0.067 | 0.0501 | -1.338 | 0.181 | -0.111 | 0.0622 | -1.781 | 0.075 |
| BSI depression score | ||||||||
| CNR1 interaction with RLE – financial | 0.061 | 0.0797 | 0.768 | 0.443 | 0.163 | 0.0660 | 2.464 | 0.014 |
| GABRA6 interaction with RLE – illness/personal | -0.087 | 0.0514 | -1.695 | 0.090 | -0.144 | 0.0633 | -2.280 | 0.023 |
BSI, Brief Symptom Inventory; S.E., standard error of beta; STAT, coefficient t-statistic; RLE, number of recent negative life events (within the last year); RLE – financial, financial difficulties; RLE-illness/personal, recent illness and personal problems; RLE – social, social network disturbances. We tested replicability of the interactions in the Budapest and Manchester subsamples. The effect allele is T in case of CNR1 rs7766029, and C in case of GABRA6 rs3219151. Significant P-values are marked in bold, and trends are marked in italic. No correction for multiple testing was applied.