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. Author manuscript; available in PMC: 2019 Apr 16.
Published in final edited form as: Bioconjug Chem. 2018 Aug 31;29(9):3180–3195. doi: 10.1021/acs.bioconjchem.8b00514

Figure 5.

Figure 5.

[18F]-TBD accumulates and is retained in apoptotic livers of Jo2-treated mice. (a) Representative PET 7.5 min post i.v. injection of female athymic nude mice with [18F]-TbD in Jo2 treated (left) versus untreated (right) mice. Open arrow indicates liver, closed arrow GI. (b) Representative PET 7.5 min post i.v. injection of of female athymic nude mice with [18F]-TBA in Jo2 treated (left) versus untreated (right) mice. Open arrow indicates liver, closed arrow GI. (c) Three-tissue compartment model used for dynamic PET analysis. (d) Kinetic parameter k3 [18F]-TBD (left) or [18F]-TBA (right) treatment. Student’s two-tailed t test p-value 0.029 for Jo2 (n = 7) vs control (n = 4), ns = not significant. (e) ROC analysis of the [18F]-TBD (left) or [18F]-TBA (right) probes.