Table 1.

Caspase-3 Activity of Fluorinated Substrates Based on Compound 1

Compound	R1	R2	R3	Hydrolyzed Product(ng)
3	CH3	Asp		32.6±1.0
4	CH3	Asp		7.0±1.1
5	CH3	Asp		3.3±1.0
6	CH3	Asp		8.3±5.0
7	CH3	Asp		0
8	CH3	Asp		0
9	CH3	Asp		4.2±0.7
10	CH3	Asp		0
11	CH3	Asp		27.3±0.6
12	CH3	Asp		11.0±1.2
13	CH3	Asp		51.7±3.8
14	CH3	Asp		22.7±7.8
15		Asp		450±9.3
16		Asp		471±4.1
17		Asp(OMe)		0.7±0.7
18		Ala		0
19		Asp		66.4±3.9
20		Asp		404±10.8
21		Asp		321±2.1